GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4693089 | 1 | rs4693089 | chr4:84373622 | MRPS18C | chr4:84377118-84389352:+ | -0.27 | -7.46 | 4.09E-13 | Menopause (age at onset) |
| THCA | cis | rs1466662 | 1 | rs4696572 | chr4:155354916 | DCHS2 | chr4:155155527-155412930:- | 0.16 | 3.46 | 0.000596 | Alzheimer's disease (age of onset) |
| THCA | cis | rs30187 | 1 | rs469758 | chr5:96121715 | CAST | chr5:95997777-96115291:+ | -0.11 | -3.92 | 0.000102 | Ankylosing spondylitis |
| THCA | cis | rs30187 | 1 | rs469758 | chr5:96121715 | ERAP1 | chr5:96096515-96149837:- | -0.39 | -11.58 | 1.63E-27 | Ankylosing spondylitis |
| THCA | cis | rs30187 | 1 | rs469758 | chr5:96121715 | ERAP2 | chr5:96211644-96255398:+ | 0.53 | 9.29 | 5.44E-19 | Ankylosing spondylitis |
| THCA | cis | rs1008375 | 1 | rs4698635 | chr4:17630242 | MED28 | chr4:17616273-17629791:+ | 0.2 | 4.42 | 1.24E-5 | Parasitemia in Tripanosoma cruzi seropositivity |
| THCA | cis | rs1008375 | 1 | rs4698641 | chr4:17642630 | MED28 | chr4:17616273-17629791:+ | 0.17 | 3.75 | 0.000202 | Parasitemia in Tripanosoma cruzi seropositivity |
| THCA | cis | rs1008375 | 1 | rs4698648 | chr4:17692715 | MED28 | chr4:17616273-17629791:+ | 0.16 | 3.43 | 0.000665 | Parasitemia in Tripanosoma cruzi seropositivity |
| THCA | cis | rs1008375 | 1 | rs4698649 | chr4:17692782 | MED28 | chr4:17616273-17629791:+ | 0.16 | 3.43 | 0.000665 | Parasitemia in Tripanosoma cruzi seropositivity |
| THCA | cis | rs1008375 | 1 | rs4698651 | chr4:17694223 | MED28 | chr4:17616273-17629791:+ | 0.15 | 3.39 | 0.00076 | Parasitemia in Tripanosoma cruzi seropositivity |
| THCA | cis | rs4698775 | 1 | rs4698775 | chr4:110590479 | CASP6 | chr4:110609785-110624629:- | -0.14 | -3.49 | 0.000523 | Age-related macular degeneration |
| THCA | cis | rs4699052 | 1 | rs4699052 | chr4:104137790 | BDH2 | chr4:103998783-104021024:- | 0.26 | 5.93 | 5.66E-9 | Testicular germ cell tumor |
| THCA | cis | rs4699052 | 1 | rs4699052 | chr4:104137790 | CISD2 | chr4:103790135-103809913:+ | -0.15 | -3.59 | 0.000369 | Testicular germ cell tumor |
| THCA | cis | rs4699052 | 1 | rs4699052 | chr4:104137790 | MANBA | chr4:103552644-103682151:- | 0.16 | 4.1 | 4.91E-5 | Testicular germ cell tumor |
| THCA | cis | rs4699052 | 1 | rs4699055 | chr4:104154500 | BDH2 | chr4:103998783-104021024:- | 0.26 | 5.95 | 5.29E-9 | Testicular germ cell tumor |